The first part of this article describes the differences in immune response against the liver fluke found in its various ruminant hosts. It shows that sensitivity to F. hepatica and F. gigantica infestation and the development of a resistance against these parasites vary widely from host to host. These host-specific responses of against the parasite, and especially the cellular response, are described. Lesions form around a necrotic area with inflammatory cells organised into a granuloma. These
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